[Translated article] Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats.

BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a cellular therapy drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. MATERIAL AND METHODS: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analysed in both groups 4 months after the repair. RESULTS: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=0.811) nor in the results of maximum load (P=0.770), displacement (P=0.852) or elastic constant (P=0.669) of the tendon in both groups. CONCLUSIONS: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.

Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats. / Eficacia del trasplante de células madre mesenquimales de lipoaspirado en el tratamiento de lesiones crónicas del manguito rotador. Modelo experimental en ratas.

BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. MATERIAL AND METHODS: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair. RESULTS: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups. CONCLUSIONS: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.

Artrodesis metatarsofalángica del hallux: comparación retrospectiva entre placa bloqueada y tornillos canulados / Hallux metatarsophalangeal arthrodesis: retrospective comparison between blocked plate and cannulated screws

Resumen: Introducción: Existen múltiples métodos e implantes utilizados para la artrodesis metatarsofalángica del hallux sin evidencia a favor de uno u otro en la bibliografía. El objetivo fue comparar los resultados clínicos y radiológicos de dos métodos e implantes utilizados en nuestro centro. Material y métodos: Revisión retrospectiva de 37 pies entre 2013 y 2017 (22 pies mediante placa y 15 mediante tornillos canulados). Se recogieron variables clínicas y radiológicas y se aplicaron las escalas AOFAS y Manchester-Oxford. Se estudiaron las variables descriptivas y analíticamente mediante el programa SPSS v15. Resultados: El grupo intervenido mediante placa lo compuso 77% de mujeres, con una edad media de 65 años y una distribución por diagnósticos de hallux valgus (HV) severo (36%), recidiva de hallux valgus (RHV) (36%) y hallux rigidus (HR) (28%), frente a 80% de mujeres, con media de 68 años y HVS (34%), RHV (46%) y HR (20%) en el grupo de tornillos canulados. No se encontró diferencias significativas en la corrección de los ángulos para HVS o RHV. La tasa de seudoartrosis dolorosa fue de 13% en ambos y la reintervención fue de 18% en el grupo de placas y 26% en el grupo de tornillos. Tanto la escala AOFAS como la M-O fueron mejores en el grupo de placa 63.8 versus 52.6 (p = 0.07); 30.1 versus 41.0 (p = 0.10); así como la satisfacción del paciente 86 versus 66% (p > 0.05) y el dolor postoperatorio 3.68 versus 5.58 (p > 0.05). Conclusión: Son grupos pequeños de estudio, sin aleatorización de implantes, ambas opciones son funcionales sin poder encontrar una preferente.

Abstract: Introduction: There are multiple methods and implants used for the metatarsophalangeal arthrodesis of hallux without evidence in favor of one or the other in the bibliography. The goal was to compare the clinical and radiological results of 2 methods and implants used in our center. Material and methods: Retrospective review of 37 feet between 2013 and 2017 (22 feet by plate and 15 by cannulated screws). Clinical and radiological variables were collected and the AOFAS and Manchester-Oxford scales were applied. Variables were studied descriptively and analytically through the SPSSv15 program. Results: The group intervened by plate was composed of 77% of women, with an average age of 65 years and a distribution by diagnosis of severe hallux valgus (HV) (36%), hallux valgus relapse (HVR) (36%) and hallux rigidus (HR) (28%), compared to 80% of women, 68 years old and HV (34%), HVR (46%) HR (20%) in the group of cannulated screws. No significant differences were found in the correction of angles for HV or HVR. The rate of painful pseudoarthrosis was 13% in both and the re-intervention was 18% in the plate group and 26% in the screw group. Both the AOFAS and M-O scales were better in the plate group 63.8 vs 52.6 (p = 0.07); 30.1 vs 41.0 (p = 0.10); as well as patient satisfaction 86% vs 66% (p > 0.05) and postoperative pain 3.68 vs 5.58 (p > 0.05). Conclusion: Small study groups, not implant randomization, both options are functional without being able to find a preferred one.

Is fibromyalgia a cause of arthroscopic subacromial decompression failure? / ¿Es la fibromialgia causa de fracaso de una descompresión subacromial artroscópica?

Isolated arthroscopic subacromial decompression (IASD) is a widely used surgical procedure with high success rates. However, up to 25% of patients experience residual pain. It is unclear whether aberrant central nervous system processing of pain as described in fibromyalgia (FM) could have a detrimental effect on outcomes. To test this hypothesis, the authors conducted a retrospective case- control study of patients undergoing IASD. MATERIAL AND METHODS: Between 2008 and 2015, 26 patients with preoperative diagnosis of fibromyalgia and an IASD procedure were identified. Six patients were lost to follow-up. Each fibromyalgia patient was matched with one control patient (n=20) recruited from the remainder with IASD. Outcomes were assessed by DASH score (Disability Arm Shoulder and Hand), Constant (CS), relative Constant score (rCS) and Visual Analogue Scale (VAS). Patient satisfaction was determined with a single 2-level question. Failure of the IASD was defined as persistent pain (VAS>3) at last follow-up. RESULTS: The average age of the sample was FM/Control group 51/48, with a mean follow-up of 36/42 months respectively. Both groups exhibited significant clinical improvement in the pain VAS, DASH and rCS at final follow-up (P<.001) compared with the preoperative scores. Mean postoperative scores FM/Control group were: Constant 63.5/74 (P=.07), rCS 82/88 (P=.18), DASH 38.9/20.7 (P=.009), VAS 3.8/2.8 (P=.2). Eighty-five percent of patients in the control group were satisfied with the surgery compared with 55% in the FM group (P=.03). Failure of the procedure was 60% in the FM group, and 30% in the control group (P=.056). CONCLUSIONS: Fibromyalgia can be considered a prognostic factor of a poor postoperative outcome after an IASD. However the clinical improvement experienced by these patients over their preoperative situation leads us to recommend their surgical treatment when indicated.

Management of pediatric tibial tubercle fractures: Is surgical treatment really necessary?

Fractures of the anterior tibial tubercle are infrequent lesions. They often occur in male adolescent athletes, usually in relation with sports involving powerful jumps. We present a retrospective study of 10 patients, with an average age of 15.1 years, all of them males, and a total of 11 acute avulsions of the anterior tibial tubercle. We analyzed the etiology of the lesion, the type of treatment used as well as non-weight bearing period, protected immobilization period, and time until sports reincorporation. We obtained 11 acute avulsions: one case of type I; three cases of type II; four cases of type III; and three cases of type IV. Five cases were treated conservatively, including the three cases of type IV, and surgery was only performed in six cases since an anatomical reduction was not obtained with closed reduction. The results were satisfactory in all cases, with 100% percentage of sport reincorporation in less de 25 weeks. We registered only one complication, intolerance of material, which did not require additional surgeries. These fractures, although rare, have an excellent prognosis. Even if they are often treated surgically, we have obtained good results with the conservative treatment in patterns previously reported as surgical.

[Hallux metatarsophalangeal arthrodesis: retrospective comparison between blocked plate and cannulated screws]. / Artrodesis metatarsofalángica del hallux: comparación retrospectiva entre placa bloqueada y tornillos canulados.

INTRODUCTION: There are multiple methods and implants used for the metatarsophalangeal arthrodesis of hallux without evidence in favor of one or the other in the bibliography. The goal was to compare the clinical and radiological results of 2 methods and implants used in our center. MATERIAL AND METHODS: Retrospective review of 37 feet between 2013 and 2017 (22 feet by plate and 15 by cannulated screws). Clinical and radiological variables were collected and the AOFAS and Manchester-Oxford scales were applied. Variables were studied descriptively and analytically through the SPSSv15 program. RESULTS: The group intervened by plate was composed of 77% of women, with an average age of 65 years and a distribution by diagnosis of severe hallux valgus (HV) (36%), hallux valgus relapse (HVR) (36%) and hallux rigidus (HR) (28%), compared to 80% of women, 68 years old and HV (34%), HVR (46%) HR (20%) in the group of cannulated screws. No significant differences were found in the correction of angles for HV or HVR. The rate of painful pseudoarthrosis was 13% in both and the re-intervention was 18% in the plate group and 26% in the screw group. Both the AOFAS and M-O scales were better in the plate group 63.8 vs 52.6 (p = 0.07); 30.1 vs 41.0 (p = 0.10); as well as patient satisfaction 86% vs 66% (p 0.05) and postoperative pain 3.68 vs 5.58 (p 0.05). CONCLUSION: Small study groups, not implant randomization, both options are functional without being able to find a preferred one.

INTRODUCCIÓN: Existen múltiples métodos e implantes utilizados para la artrodesis metatarsofalángica del hallux sin evidencia a favor de uno u otro en la bibliografía. El objetivo fue comparar los resultados clínicos y radiológicos de dos métodos e implantes utilizados en nuestro centro. MATERIAL Y MÉTODOS: Revisión retrospectiva de 37 pies entre 2013 y 2017 (22 pies mediante placa y 15 mediante tornillos canulados). Se recogieron variables clínicas y radiológicas y se aplicaron las escalas AOFAS y Manchester-Oxford. Se estudiaron las variables descriptivas y analíticamente mediante el programa SPSS v15. RESULTADOS: El grupo intervenido mediante placa lo compuso 77% de mujeres, con una edad media de 65 años y una distribución por diagnósticos de hallux valgus (HV) severo (36%), recidiva de hallux valgus (RHV) (36%) y hallux rigidus (HR) (28%), frente a 80% de mujeres, con media de 68 años y HVS (34%), RHV (46%) y HR (20%) en el grupo de tornillos canulados. No se encontró diferencias significativas en la corrección de los ángulos para HVS o RHV. La tasa de seudoartrosis dolorosa fue de 13% en ambos y la reintervención fue de 18% en el grupo de placas y 26% en el grupo de tornillos. Tanto la escala AOFAS como la M-O fueron mejores en el grupo de placa 63.8 versus 52.6 (p = 0.07); 30.1 versus 41.0 (p = 0.10); así como la satisfacción del paciente 86 versus 66% (p 0.05) y el dolor postoperatorio 3.68 versus 5.58 (p 0.05). CONCLUSIÓN: Son grupos pequeños de estudio, sin aleatorización de implantes, ambas opciones son funcionales sin poder encontrar una preferente.

[Dislocation of the proximal hallux interphalangeal joint with interposition of a sesamoid bone: a blibliographic review]. / Luxación de la articulación interfalángica proximal del hallux con interposición de un hueso sesamoideo: una revisión bibliográfica.

The irreducible dislocation of the hallux interphalangeal joint is an infrequent condition and only a few cases have been described. It presents as dorsal dislocation with interposition of the sesamoid bone, which has the possibility of being radiologically undetectable. We present the case of a 29 year-old patient who, after a sports trauma sustained a hallux interphalangeal dislocation that went unnoticed for eight days. Since, closed reduction was not possible, as occurred in several cases reported in the literature, open reduction was performed through a dorsal incision. Based on a bibliographic review, it is possible to state that there are several treatment options and multiple approaches, and that these lesions usually have a good prognosis.

La luxación irreductible de la articulación interfalángica del hallux es una patología poco frecuente y hay pocos casos descritos. Se presenta como una luxación dorsal con interposición del sesamoideo; éste puede ser radiológicamente indetectable. Reportamos el caso de un paciente de 29 años que tras un traumatismo deportivo presentó una luxación interfalángica del hallux que pasó desapercibida hasta el octavo día. Al igual que en varios casos descritos en la literatura, no se pudo realizar una reducción cerrada, por lo que se procedió a una reducción abierta por una incisión dorsal. Una revisión bibliográfica revela que existen varias opciones terapéuticas, al igual que múltiples tipos de abordajes, y que estas lesiones generalmente presentan un buen pronóstico.

Luxación de la articulación interfalángica proximal del hallux con interposición de un hueso sesamoideo: una revisión bibliográfica / Dislocation of the proximal hallux interphalangeal joint with interposition of a sesamoid bone: a blibliographic review

Resumen: La luxación irreductible de la articulación interfalángica del hallux es una patología poco frecuente y hay pocos casos descritos. Se presenta como una luxación dorsal con interposición del sesamoideo; éste puede ser radiológicamente indetectable. Reportamos el caso de un paciente de 29 años que tras un traumatismo deportivo presentó una luxación interfalángica del hallux que pasó desapercibida hasta el octavo día. Al igual que en varios casos descritos en la literatura, no se pudo realizar una reducción cerrada, por lo que se procedió a una reducción abierta por una incisión dorsal. Una revisión bibliográfica revela que existen varias opciones terapéuticas, al igual que múltiples tipos de abordajes, y que estas lesiones generalmente presentan un buen pronóstico.

Abstract: The irreducible dislocation of the hallux interphalangeal joint is an infrequent condition and only a few cases have been described. It presents as dorsal dislocation with interposition of the sesamoid bone, which has the possibility of being radiologically undetectable. We present the case of a 29 year-old patient who, after a sports trauma sustained a hallux interphalangeal dislocation that went unnoticed for eight days. Since, closed reduction was not possible, as occurred in several cases reported in the literature, open reduction was performed through a dorsal incision. Based on a bibliographic review, it is possible to state that there are several treatment options and multiple approaches, and that these lesions usually have a good prognosis.

Repair of rotator cuff injuries using different composites. / Reparación de las lesiones crónicas del manguito rotador mediante diferentes compuestos.

AIM: Rotator cuff repairs have shown a high level of re-ruptures. It is hypothesised that the use of rhBMP-2 in a carrier could improve the biomechanical and histological properties of the repair. MATERIAL AND METHODS: Controlled experimental study conducted on 40 rats with section and repair of the supraspinatus tendon and randomisation to one of five groups: Group 1 (control) only suture; Group 2 (double control), suture and alginate-chitin carrier; Group 3 (alginate-control), the rhBMP-2 was added to the alginate; Group 4 (chitin-control) application of the rhBMP-2 to the chitin, and Group 5 (double sample): The two components of the carrier (alginate and chitin) have rhBMP-2. A biomechanical and histological analysis was performed at 4 weeks. RESULTS: A gap was observed in all cases 4 weeks after supraspinatus detachment. The re-rupture rate was 7.5%, with 20% of them in the control-alginate Group. Histologically the best results were obtained in the double sample group: 4.5 (3.3-5.0). Double sample were also able to support higher loads to failure: 62.9N (59.8 to 69.4) with lower rigidity 12.7 (9.7 to 15.9). CONCLUSIONS: The use of alginate-chitin carrier with rhBMP-2 improves the biomechanical and histological properties of the repair site in a chronic rotator cuff tear.

[Surgical treatment of malignant primary tumors of the pelvis on Ennekings zone II]. / Tratamiento quirúrgico de los tumores primarios malignos de pelvis de la zona II de Enneking.

INTRODUCTION: Surgical treatment of malignant bone tumors of the pelvis with periacetabular involvement is constantly evolving. Even though acetabular reconstructions improve quality of life without impairing cancer control, they are not complication free. Our purpose is to describe the functional outcomes and surgical complications of different reconstructive techniques for Enneking zone II tumors. MATERIAL AND METHODS: Fifteen patients underwent surgery for malignant pelvic bone tumors between 2002 and 2012. Seven patients were retrospectively evaluated according to the Enneking and Dunham classification and were found to have periacetabular involvement, as follows: 3 were type II; 1 types I + II; 2 types II + III, and one types I + II + III. Five patients had a standard chondrosarcoma and 2 osteosarcoma. Patients included 4 males and 3 females; mean age was 43 years. The minimum follow-up period was 12 months (mean 6.14 years). All of them underwent cancer resection with periacetabular reconstruction: massive osteochondral allograft in 3 patients, structural allograft and hip arthroplasty in 2 patients, and prosthesis with iliac anchoring in 2. They were clinically, radiologically and functionally evaluated with the MSTS scale (1993). RESULTS: The mean MSTS score 6 months after surgery was 20.71 (69%). Five patients (71.4%) had surgical complications: 2 dislocations of the native femoral head on the allograft; one aseptic prosthetic dislodgement, and 2 deep infections. All patients had free intraoperative borders. CONCLUSIONS: Acetabular reconstructions after oncologic resection for malignant bone tumors seem to provide good functional outcomes. However, only selected cases should undergo surgeries associated with a high complication rate.

El tratamiento quirúrgico de los tumores óseos malignos de pelvis con afectación periacetabular está en continua evolución. Las reconstrucciones acetabulares mejoran la calidad de vida sin perjudicar el control oncológico; sin embargo, no están exentas de complicaciones. Nuestro objetivo es describir los resultados funcionales y las complicaciones quirúrgicas de diferentes técnicas reconstructivas de la zona II de Enneking.

[Congenital knee dislocation: case report]. / Luxación congénita de rodilla: a propósito de un caso.

Congenital knee dislocation is an infrequent condition with unknown etiology. In some cases it occurs as an isolated condition, while in others it coexists with associated conditions or syndromes. The treatment of congenital knee dislocation is driven by the severity and flexibility of the deformity. The literature includes from serial casting or the Pavlik harness to quadriceps tendon plasty or femoral osteotomies. We report herein the case of a congenital dislocation treated with serial casting with a good outcome.

La luxación congénita de rodilla es una patología poco frecuente con una etiología desconocida. En algunos casos se le considera una patología aislada mientras que en otros pueden observarse patologías asociadas o síndromes. El tratamiento de la luxación congénita de rodilla depende de la gravedad y flexibilidad de la deformidad y en la bibliografía pueden encontrarse desde enyesados seriados o arnés de Pavlik hasta plastías del tendón cuadricipital u osteotomías femorales. Presentamos un caso de una luxación congénita que se trató mediante enyesado seriado y que evolucionó favorablemente.

Luxación congénita de rodilla: a propósito de un caso / Congenital knee dislocation: case report

Resumen: La luxación congénita de rodilla es una patología poco frecuente con una etiología desconocida. En algunos casos se le considera una patología aislada mientras que en otros pueden observarse patologías asociadas o síndromes. El tratamiento de la luxación congénita de rodilla depende de la gravedad y flexibilidad de la deformidad y en la bibliografía pueden encontrarse desde enyesados seriados o arnés de Pavlik hasta plastías del tendón cuadricipital u osteotomías femorales. Presentamos un caso de una luxación congénita que se trató mediante enyesado seriado y que evolucionó favorablemente.

Abstract: Congenital knee dislocation is an infrequent condition with unknown etiology. In some cases it occurs as an isolated condition, while in others it coexists with associated conditions or syndromes. The treatment of congenital knee dislocation is driven by the severity and flexibility of the deformity. The literature includes from serial casting or the Pavlik harness to quadriceps tendon plasty or femoral osteotomies. We report herein the case of a congenital dislocation treated with serial casting with a good outcome.

Tratamiento quirúrgico de los tumores primarios malignos de pelvis de la zona II de Enneking / Surgical treatment of malignant primary tumors of the pelvis on Enneking's zone II

Resumen: Introducción: El tratamiento quirúrgico de los tumores óseos malignos de pelvis con afectación periacetabular está en continua evolución. Las reconstrucciones acetabulares mejoran la calidad de vida sin perjudicar el control oncológico; sin embargo, no están exentas de complicaciones. Nuestro objetivo es describir los resultados funcionales y las complicaciones quirúrgicas de diferentes técnicas reconstructivas de la zona II de Enneking. Material y métodos: 15 pacientes fueron intervenidos de tumores óseos malignos de pelvis entre 2002 y 2012. Según la clasificación de Enneking y Dunham, hubo siete individuos con afectación periacetabular: tipo II-3, tipo I + II-1, tipo II + III-2, tipo I + II + III-1, que se evaluaron retrospectivamente. Cinco presentaron un condrosarcoma convencional y dos un osteosarcoma. Cuatro eran varones y tres mujeres, con una edad media de 43 años. El seguimiento mínimo fue 12 meses (6.14 años de media). En todos se realizó una resección oncológica con reconstrucción periacetabular: aloinjerto osteocondral masivo en tres sujetos, aloinjerto estructural más artroplastía de cadera en dos personas y dos con prótesis de anclaje ilíaco. Fueron evaluados clínica, radiológica y funcionalmente mediante la escala MSTS (1993). Resultados: La media MSTS a los seis meses de la cirugía fue 20.71 (69%). Complicaciones quirúrgicas aparecieron en cinco casos (71.4%): dos luxaciones de cabeza femoral nativa sobre aloinjerto, una desimplantación protésica aséptica y dos infecciones profundas. Hubo bordes libres intraoperatorios en todos los casos. Conclusiones: Las reconstrucciones acetabulares después de resecciones oncológicas en tumores óseos malignos parecen ofrecer buenos resultados funcionales. Sin embargo, sólo casos seleccionados deberían ser sometidos a intervenciones con alta tasa de complicaciones.

Abstract: Introduction: Surgical treatment of malignant bone tumors of the pelvis with periacetabular involvement is constantly evolving. Even though acetabular reconstructions improve quality of life without impairing cancer control, they are not complication free. Our purpose is to describe the functional outcomes and surgical complications of different reconstructive techniques for Enneking zone II tumors. Material and methods: Fifteen patients underwent surgery for malignant pelvic bone tumors between 2002 and 2012. Seven patients were retrospectively evaluated according to the Enneking and Dunham classification and were found to have periacetabular involvement, as follows: 3 were type II; 1 types I + II; 2 types II + III, and one types I + II + III. Five patients had a standard chondrosarcoma and 2 osteosarcoma. Patients included 4 males and 3 females; mean age was 43 years. The minimum follow-up period was 12 months (mean 6.14 years). All of them underwent cancer resection with periacetabular reconstruction: massive osteochondral allograft in 3 patients, structural allograft and hip arthroplasty in 2 patients, and prosthesis with iliac anchoring in 2. They were clinically, radiologically and functionally evaluated with the MSTS scale (1993). Results: The mean MSTS score 6 months after surgery was 20.71 (69%). Five patients (71.4%) had surgical complications: 2 dislocations of the native femoral head on the allograft; one aseptic prosthetic dislodgement, and 2 deep infections. All patients had free intraoperative borders. Conclusions: Acetabular reconstructions after oncologic resection for malignant bone tumors seem to provide good functional outcomes. However, only selected cases should undergo surgeries associated with a high complication rate.